HORDB

ID: hor004432
Uniprot ID: P41540
Protein name: Neurokinin A
Gene name: Tac1
Organism: Oryctolagus cuniculus (Rabbit)
Family: Tachykinin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Oryctolagus (genus), Leporidae (family), Lagomorpha (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007217 tachykinin receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission
GO CC: GO:0005576 extracellular region; GO:0045202 synapse

Sequence: HKTDSFVGLM
Length: 10(83-92)
Propeptide: MKILVALAVLALVSTQLFAEDIRANDDLNYWSDWSDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDAGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK
Signal peptide: MKILVALAVLALVSTQLFA
Modification: T10 Methionine amide
Glycosylation: NA
Mutagenesis: NA

Function: Excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004432_AF2.pdb

hor004432_ESM.pdb

Mass:	129503	Formula:	C50H79N13O15S
Absent amino acids:	ACEINPQRWY	Common amino acids:	DFGHKLMSTV
pI:	7.55	Basic residues:	2
Polar residues:	3	Hydrophobic residues:	3
Hydrophobicity:	2	Boman Index:	-967
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	68
Instability Index:	4345	Extinction Coefficient cystines:	0
Absorbance 280nm:	0